Lichen sclerosus

J Am Acad Dermatol. 1995 Mar;32(3):393-416; quiz 417-8. doi: 10.1016/0190-9622(95)90060-8.


Lichen sclerosus, usually appearing in the dermatologic literature under the names of lichen sclerosus et atrophicus, balanitis xerotica obliterans, and kraurosis vulvae, is an inflammatory disease with a multifactorial origin. A past association of lichen sclerosus and genital squamous cell carcinoma is not as close as once thought. Once considered primarily a surgical problem, especially when the genitals were involved, lichen sclerosus will respond to a variety of systemic and topical therapies.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / etiology
  • Diagnosis, Differential
  • Female
  • Genital Diseases, Female / pathology
  • Genital Diseases, Female / therapy
  • Genital Diseases, Male / pathology
  • Genital Diseases, Male / therapy
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Lichen Sclerosus et Atrophicus* / classification
  • Lichen Sclerosus et Atrophicus* / diagnosis
  • Lichen Sclerosus et Atrophicus* / etiology
  • Lichen Sclerosus et Atrophicus* / history
  • Lichen Sclerosus et Atrophicus* / therapy
  • Male
  • Scleroderma, Localized / diagnosis