Variability of protection in inbred mice induced by a ribosomal vaccine prepared from Salmonella typhimurium

Infect Immun. 1976 Sep;14(3):652-9. doi: 10.1128/iai.14.3.652-659.1976.


Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J inbred mice and C3H/HeTex, inbred mice. However, ribosomal vaccines were not protective in C57BL/6J inbred mice. A/J mice were protected against lethal challenge by attenuated S. typhimurium live-cell, ribosomal, phenol, and heat-killed vaccines. C3H/HeTex mice were protected by live-cell, ribosomal, and phenol vaccines but not the heat-killed vaccine. Only the live-cell vaccine gave significant protection in the C57BL/6J inbred mice. A comparison of the kinetics of infection in sham-immunized mice and mice immunized with ribosomes showed that ribosome preparations elicited protection against Salmonella infection in mice inherently sensitive and resistant to Salmonella.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacterial Vaccines* / administration & dosage
  • Kinetics
  • Male
  • Mice
  • Mice, Inbred Strains
  • Ribosomes / immunology*
  • Salmonella Infections, Animal / prevention & control*
  • Salmonella typhimurium / immunology*
  • Species Specificity
  • Vaccination


  • Bacterial Vaccines