Inhaled nitric oxide for premature infants after prolonged rupture of the membranes

J Pediatr. 1995 Mar;126(3):450-3. doi: 10.1016/s0022-3476(95)70467-1.


We evaluated the use of inhaled nitric oxide in eight premature infants (520 to 1440 gm, 24 to 31 weeks of gestation) who failed to respond to conventional management and who had prolonged rupture of the membranes and oligohydramnios. All infants had a significant improvement in oxygenation and a fall in mean airway pressure with inhaled nitric oxide. Further studies are required to determine the safety and efficacy of this form of therapy.

MeSH terms

  • Administration, Inhalation
  • Evaluation Studies as Topic
  • Female
  • Fetal Membranes, Premature Rupture / complications
  • Humans
  • Hypoxia / therapy*
  • Infant, Newborn
  • Infant, Premature*
  • Nitric Oxide / therapeutic use*
  • Oligohydramnios / complications
  • Oxygen Inhalation Therapy
  • Pregnancy
  • Treatment Outcome


  • Nitric Oxide