CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats

Psychopharmacology (Berl). 1994 Aug;115(4):435-40. doi: 10.1007/BF02245565.


Modulation of learning and memory is one of the physiological roles that the neuropeptide cholecystokinin (CCK-8) may play. We have used a behavioural model of olfactory recognition among rats to test this hypothesis and to explore the relationship between CCK-A and CCK-B receptors and memory retention. Adult male rats form a transient memory of a juvenile congenere as indicated by a reduction in the duration of investigatory behaviour upon re-exposure 30 min after an initial exposure, but not when re-exposure is delayed until 120 min afterwards. In the present study, rats were treated after the first contact with various compounds; inhibition and facilitation of olfactory recognition were evaluated as the persistence in investigation 30 min and the decrease in investigation 120 min after pharmacological manipulations, respectively. Systemic injection of CCK-8, of a selective CCK-A agonist, or of non-peptide CCK-B antagonists (CI-988 and LY-262691) enhanced olfactory recognition. In contrast, the CCK-B selective agonist BC 264 and the tetrapeptide CCK-4 both disrupted it. Taken together with previous evidence of the detrimental effect of the nonpeptide. CCK-A antagonist devazepide on olfactory recognition, these results confirm and extend the hypothesis that there is a balance between CCK-A-mediated facilitative effects and CCK-B-mediated inhibitory effects on memory retention.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Benzodiazepinones / pharmacology
  • Cholecystokinin / analogs & derivatives
  • Cholecystokinin / antagonists & inhibitors
  • Cholecystokinin / pharmacology
  • Cognition / drug effects*
  • Indoles / pharmacology
  • Male
  • Meglumine / analogs & derivatives
  • Meglumine / pharmacology
  • Molecular Sequence Data
  • Peptide Fragments / pharmacology
  • Phenylurea Compounds*
  • Pyrazoles / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Cholecystokinin / agonists*
  • Receptors, Cholecystokinin / antagonists & inhibitors*
  • Sincalide / pharmacology
  • Smell / drug effects*
  • Social Behavior


  • BC 264
  • Benzodiazepinones
  • Indoles
  • Peptide Fragments
  • Phenylurea Compounds
  • Pyrazoles
  • Receptors, Cholecystokinin
  • PD 134308
  • 1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone
  • L 365260
  • Meglumine
  • Cholecystokinin
  • Sincalide