GAPs for rho-related GTPases

Trends Genet. 1994 Dec;10(12):436-40. doi: 10.1016/0168-9525(94)90114-7.


Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified. Here, we discuss the nature of such GTPase-activating proteins (GAPs) and their potential importance for cell signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / metabolism
  • Drosophila / metabolism
  • GTP Phosphohydrolases / metabolism*
  • GTP-Binding Proteins / metabolism*
  • GTPase-Activating Proteins*
  • Humans
  • Mammals
  • Saccharomyces cerevisiae / metabolism


  • GTPase-Activating Proteins
  • rho GTPase-activating protein
  • GTP Phosphohydrolases
  • GTP-Binding Proteins