Treatment of idiopathic renal magnesium wasting with amiloride

Am J Nephrol. 1995;15(1):75-7. doi: 10.1159/000168804.


We report a case of an 18-year-old female who presented with severe hypomagnesmia due to idiopathic renal magnesium wasting. Only a partial response was noted with magnesium oxide replacement. Treatment with the potassium-sparing diuretic amiloride led to a further rise in the serum magnesium level, a decrease in the fractional excretion of magnesium and improvement in her symptoms. This case demonstrates an effective treatment for idiopathic renal magnesium wasting.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Amiloride / therapeutic use*
  • Female
  • Humans
  • Kidney Tubules / metabolism
  • Magnesium / blood*
  • Magnesium / metabolism
  • Renal Tubular Transport, Inborn Errors / complications
  • Renal Tubular Transport, Inborn Errors / drug therapy*
  • Water-Electrolyte Imbalance / drug therapy*
  • Water-Electrolyte Imbalance / etiology


  • Amiloride
  • Magnesium