Breast cancer response to adjuvant chemotherapy in correlation with erbB2 and p53 expression

Anticancer Res. Nov-Dec 1994;14(6B):2773-8.

Abstract

The expression of the erbB2 and p53 proteins was examined by immunohistochemistry in a series of 81 cases of primary breast carcinomas treated with an adjuvant chemotherapy with a median follow-up of 5 years. Expression of erbB2 was present in 19 cases (23%), 50% of them with more than 70% of positive tumoral cells. Expression of p53 was present in 32 cases (39%), 50% of them with more than 30% of positive tumoral cells; coexpression of erbB2 and p53 was observed in 11 cases (13.5%). Disease-free and overall survival of the patients were correlated with the number of positive lymph nodes (p = 0.08, p = 0.015). No significant trend was observed in response to adjuvant chemotherapy in correlation with erbB2 or p53 expression or both, whatever the level of expression.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biomarkers, Tumor / analysis
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Chemotherapy, Adjuvant*
  • Cisplatin / administration & dosage
  • Female
  • Fluorouracil / administration & dosage
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Methotrexate / administration & dosage
  • Middle Aged
  • Mitoxantrone / therapeutic use
  • Ovariectomy
  • Predictive Value of Tests
  • Prognosis
  • Receptor, ErbB-2 / analysis
  • Receptor, ErbB-2 / biosynthesis*
  • Tamoxifen / therapeutic use
  • Tumor Suppressor Protein p53 / analysis
  • Tumor Suppressor Protein p53 / biosynthesis*

Substances

  • Biomarkers, Tumor
  • Tumor Suppressor Protein p53
  • Tamoxifen
  • Mitoxantrone
  • Receptor, ErbB-2
  • Cisplatin
  • Fluorouracil
  • Methotrexate

Supplementary concepts

  • CMF protocol