Increased serotonin levels in physically trained men

Braz J Med Biol Res. 1994 Jul;27(7):1635-8.


It has been postulated that exercise training influences monoaminergic systems. The purpose of the present study was to determine the basal level of serum serotonin (5HT) in track and field-trained men (N = 15) and in untrained subjects matched by age, weight and height (N = 15). Serum serotonin levels were determined in blood drawn into dry tubes after a 12-h fast by high performance liquid chromatography utilizing electrochemical detection. Mean (+/- SD) serum serotonin levels were: 141.32 +/- 38.77 ng/ml for trained subjects and 97.77 +/- 30.53 ng/ml for untrained subjects (P < 0.01, Student t-test). These data show that basal serum serotonin levels are increased by exercise training.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Body Constitution
  • Exercise / physiology*
  • Humans
  • Male
  • Physical Fitness*
  • Serotonin / blood*


  • Serotonin