Degeneration model of the porcine lumbar motion segment: effects of various intradiscal procedures

Eur Spine J. 1994;3(1):8-16. doi: 10.1007/BF02428310.


In an experimental study with 18 minipigs, we have tried to establish a model for the standardized evaluation of mechanical, histological and radiological phenomena of degenerative and reparative processes within the lumbar motion segment. Comparing different operative techniques revealed that the intradiscal application of hyaluronic acid into the nuclear defect is likely to enhance the regeneration process. Using the measurement of disc compliance, a semiautomatic picture analyzer and a new semiquantitative disc score could make future studies more comparable. From this basis, the intradiscal application of hyaluronic acid deserves further evaluation.

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Hyaluronic Acid / therapeutic use
  • Intervertebral Disc Chemolysis
  • Lumbar Vertebrae / pathology
  • Lumbar Vertebrae / physiopathology*
  • Pressure
  • Random Allocation
  • Regeneration / drug effects
  • Spinal Diseases / etiology*
  • Spinal Diseases / pathology
  • Spinal Diseases / physiopathology
  • Spinal Diseases / therapy
  • Swine
  • Swine, Miniature


  • Hyaluronic Acid