Tc-99m sulfur colloid demonstration of diffuse pulmonary interstitial extramedullary hematopoiesis in a patient with myelofibrosis. A case report and review of the literature

Clin Nucl Med. 1994 Dec;19(12):1079-84. doi: 10.1097/00003072-199419120-00009.


A 60-year-old man with a myeloproliferative syndrome and extramedullary hematopoiesis had progressive respiratory and cardiac insufficiency during the previous 18 months, with advancing interstitial pulmonary disease on chest x-ray. During analysis of his respiratory disease, results of a transbronchial biopsy showed interstitial involvement with increased numbers of megakaryocytes and other panhematopoietic staining elements. Results of a bone marrow scan demonstrated diffuse replacement of pulmonary interstitium with bone marrow, as a component of known ongoing extramedullary hematopoiesis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Bone Marrow / diagnostic imaging
  • Hematopoiesis, Extramedullary*
  • Humans
  • Lung / diagnostic imaging*
  • Lung Diseases, Interstitial / diagnostic imaging*
  • Lung Diseases, Interstitial / etiology
  • Male
  • Middle Aged
  • Primary Myelofibrosis / diagnostic imaging*
  • Primary Myelofibrosis / physiopathology
  • Radionuclide Imaging
  • Technetium Tc 99m Sulfur Colloid*


  • Technetium Tc 99m Sulfur Colloid