Localization of type I interleukin-1 receptor mRNA in the rat brain

Brain Res Mol Brain Res. 1994 Nov;27(1):27-36. doi: 10.1016/0169-328x(94)90180-5.


The distribution of type I interleukin-1 receptor (IL-1R1) mRNA in the rat brain was examined by in situ hybridization technique. IL-1R1 mRNA was expressed in several brain regions including the anterior olfactory nucleus, medial thalamic nucleus, posterior thalamic nucleus, basolateral amygdaloid nucleus, ventromedial hypothalamic nucleus, arcuate nucleus, median eminence, mesencephalic trigeminal nucleus, motor trigeminal nucleus, facial nucleus and Purkinje cells of the cerebellum. Furthermore, we identified neuronal expression of IL-1R1 mRNA using simultaneous detection (double in situ hybridization) of IL-1R1 mRNA with neuron specific enolase mRNA. In addition to the expression in neuronal cells, IL-1R1 mRNA was also expressed on the vascular walls and the epithelial cells of the choroid plexus and the ventricles. These findings suggest the possibility that IL-1 produces its multiple effects on the central nervous system through the actions not only on neuronal cells but also on endothelial and epithelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Chemistry*
  • Cerebral Ventricles / blood supply
  • Choroid Plexus / blood supply
  • Endothelium, Vascular / metabolism
  • Epithelium / metabolism
  • In Situ Hybridization
  • Nerve Tissue Proteins / biosynthesis*
  • Nerve Tissue Proteins / genetics
  • Neurons / metabolism
  • Phosphopyruvate Hydratase / biosynthesis
  • Phosphopyruvate Hydratase / genetics
  • RNA Probes
  • RNA, Messenger / analysis*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Interleukin-1 / biosynthesis*
  • Receptors, Interleukin-1 / genetics


  • Nerve Tissue Proteins
  • RNA Probes
  • RNA, Messenger
  • Receptors, Interleukin-1
  • Phosphopyruvate Hydratase