Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 12 (1), 123-30

Functional Constraints Against Variations on Molecules From the Tissue Level: Slowly Evolving Brain-Specific Genes Demonstrated by Protein Kinase and Immunoglobulin Supergene Families

Affiliations
Comparative Study

Functional Constraints Against Variations on Molecules From the Tissue Level: Slowly Evolving Brain-Specific Genes Demonstrated by Protein Kinase and Immunoglobulin Supergene Families

K Kuma et al. Mol Biol Evol.

Abstract

In the protein kinase family, the basic function of kinase domain is similar among members. According to the standard view of functional constraint, the molecular evolutionary rate depends on functional and structural features characteristic of individual molecules (local constraint). Thus the evolutionary rate of the kinase domain is expected to be similar for different members. Contrary to this expectation, a comparison of the evolutionary rates revealed a wide difference among members; it amounts to about 100 times difference between the maximum and minimum rates. A similar result was also found in members of the immunoglobulin (Ig) family. In addition, significant correlations in evolutionary rate were observed between the kinase domain and the Ig-like domain in the receptor protein tyrosine kinases and between the kinase domain and the SH domain in the nonreceptor-type kinases. Furthermore, the evolutionary rates of family members that are expressed tissue specifically differ widely, depending on their tissue distribution: members expressed in the brain evolve with significantly slower rates than those expressed in the immune system. These results strongly suggest the presence of an alternative constraint (global constraint) against changes on molecules derived from higher levels like tissues or organs.

Similar articles

See all similar articles

Cited by 14 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback