Systemic bacterial and fungal infections in infants in Australian neonatal units. Australian Study Group for Neonatal Infections

Med J Aust. 1995 Feb 20;162(4):198-201. doi: 10.5694/j.1326-5377.1995.tb126024.x.


Objective: To examine the pattern and incidence of sepsis occurring in neonatal units in Australia.

Design: A one-year prospective study of babies with systemic sepsis within 48 hours of birth (early-onset sepsis) or after this time (late-onset sepsis) in seven Australian neonatal units. Systemic sepsis was defined as clinical sepsis, plus either positive bacterial or fungal culture of blood and/or cerebrospinal fluid, or group B streptococcal antigen detected in the urine.

Results: There were 241 episodes of sepsis, affecting 234 babies. One quarter (61) were early-onset, a rate of 2.2 per 1000 live births. Group B streptococcus (GBS) was the commonest cause of early-onset sepsis, with a rate of 1.3 per 1000 live births. The incidence of early-onset GBS sepsis was lower at a hospital which screened for maternal carriage and used intrapartum antibiotic prophylaxis for all carriers. The rate of late-onset sepsis was 4.4 per 1000 live births and coagulase-negative staphylococci were the commonest cause. Meningitis occurred in 23% of babies with early-onset and in 10% with late-onset sepsis. The mortality from early-onset sepsis was 15%, and from late-onset sepsis was 9%. There were no major regional variations, other than for GBS.

Conclusions: The incidence of and mortality from neonatal sepsis is comparable to other countries, and shows no major regional variation. The use of intrapartum antibiotics may reduce the incidence of neonatal GBS sepsis. There are no previous comparable data on neonatal infections in Australia.

Publication types

  • Multicenter Study
  • Review

MeSH terms

  • Australia / epidemiology
  • Bacterial Infections / epidemiology*
  • Bacterial Infections / microbiology
  • Cross Infection / epidemiology
  • Humans
  • Incidence
  • Infant, Newborn
  • Intensive Care Units, Neonatal / statistics & numerical data*
  • Mycoses / epidemiology*
  • Mycoses / microbiology
  • Population Surveillance
  • Prospective Studies
  • Sepsis / epidemiology*
  • Sepsis / microbiology