The G-protein-gated Atrial K+ Channel IKACh Is a Heteromultimer of Two Inwardly Rectifying K(+)-channel Proteins

Nature. 1995 Mar 9;374(6518):135-41. doi: 10.1038/374135a0.

Abstract

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate IKACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K(+)-channel gene, GIRK1, alone encodes IKACh. It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Line
  • Cloning, Molecular
  • Dogs
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • GTP-Binding Proteins / metabolism
  • Ion Channel Gating
  • Membrane Potentials
  • Molecular Sequence Data
  • Myocardium / metabolism*
  • Oocytes
  • Potassium Channels / chemistry*
  • Potassium Channels / genetics
  • Potassium Channels / metabolism*
  • Potassium Channels, Inwardly Rectifying*
  • Protein Conformation
  • Rats
  • Recombinant Proteins
  • Xenopus

Substances

  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • Kcnj5 protein, rat
  • Potassium Channels
  • Potassium Channels, Inwardly Rectifying
  • Recombinant Proteins
  • GTP-Binding Proteins

Associated data

  • GENBANK/L35771