Antitumor therapy has expanded beyond the previous notions of cytotoxic or biologic therapy to now include agents that induce differentiation (e.g. all trans-retinoic acid for induction of complete remission in patients with acute promyelocytic leukemia ) or apoptosis . In fact, the phenomenon of apoptosis may be fundamental to the current understanding of carcinogenesis  and may also underlie the effectiveness of some forms of chemotherapy [4,5,18,39,56,59,67], radiation therapy [19,44,52,60,64, 77,78,85] and the interferons . The process of apoptosis has been shown to be responsible for the normal elimination of cells with damaged DNA  as well as other potentially dangerous cells such as autoreactive T-lymphocytes . Therefore, although much attention has been given to oncogenes that induce cellular proliferation, one can easily see how the same result (i.e. neoplasia) could be obtained when the ability of a cell to undergo apoptosis is lost.