Leflunomide (HWA 486) and its analog suppress T- and B-cell proliferation in vitro, acute rejection, ongoing rejection, and antidonor antibody synthesis in mouse, rat, and cynomolgus monkey transplant recipients as well as arterial intimal thickening after balloon catheter injury

Transplant Proc. 1995 Feb;27(1):445-7.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aniline Compounds / pharmacology*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Arteries / drug effects
  • Arteries / pathology
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology*
  • Catheterization / adverse effects
  • Crotonates
  • Cyclosporine / therapeutic use
  • Graft Rejection / immunology
  • Graft Rejection / prevention & control*
  • Graft Survival / drug effects*
  • Graft Survival / immunology
  • Heart Transplantation / immunology*
  • Hydroxybutyrates / pharmacology*
  • Immunosuppressive Agents / pharmacology*
  • Isoxazoles / pharmacology*
  • Leflunomide
  • Lymphocyte Activation / drug effects*
  • Macaca fascicularis
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Nitriles
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred Lew
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • Toluidines
  • Transplantation, Homologous
  • Tunica Intima / drug effects*
  • Tunica Intima / pathology

Substances

  • Aniline Compounds
  • Anti-Inflammatory Agents, Non-Steroidal
  • Crotonates
  • Hydroxybutyrates
  • Immunosuppressive Agents
  • Isoxazoles
  • Nitriles
  • Toluidines
  • teriflunomide
  • Cyclosporine
  • Leflunomide