The immunology of exceptional individuals: the lesson of centenarians

Immunol Today. 1995 Jan;16(1):12-6. doi: 10.1016/0167-5699(95)80064-6.


Centenarians are the best example of successful ageing, since they have escaped the major age-associated diseases, and most are in good mental and physical condition. Here, Claudio Franceschi and colleagues discuss how the study of their immune systems reveals that several immune parameters are well conserved, suggesting that a complex remodelling of most immune parameters occurs with age, rather than a unidirectional deterioration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / immunology*
  • B-Lymphocytes / immunology*
  • Humans
  • Immune System
  • Lymphocyte Activation
  • T-Lymphocytes / immunology*