Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

Immunol Today. 1995 Jan;16(1):34-8. doi: 10.1016/0167-5699(95)80068-9.


CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • CD4-Positive T-Lymphocytes / immunology
  • Diabetes Mellitus, Type 1 / immunology
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*