Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

Curr Opin Cell Biol. 1994 Dec;6(6):788-94. doi: 10.1016/0955-0674(94)90046-9.


Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Helix-Loop-Helix Motifs / physiology
  • Muscle, Skeletal / cytology*
  • MyoD Protein / physiology
  • Oncogene Proteins / physiology
  • Rhabdomyosarcoma


  • MyoD Protein
  • Oncogene Proteins