Differentiation and self-renewal in the mouse gastrointestinal epithelium

Curr Opin Cell Biol. 1994 Dec;6(6):795-803. doi: 10.1016/0955-0674(94)90047-7.


The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are now available for identifying the molecular mechanisms that regulate cell fate in the gut, the migration-associated differentiation programs of its component cell lineages, and its axial patterning. Considerable attention needs to be paid to two variables when studying gastrointestinal epithelial cell biology: space and time. This has necessitated the use of normal, chimeric, and transgenic animals as experimental models.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Digestive System / cytology*
  • Digestive System / embryology
  • Epithelial Cells
  • Forecasting
  • Gene Expression Regulation, Developmental
  • Mice
  • Mice, Transgenic