Cdk inhibitors: on the threshold of checkpoints and development

Curr Opin Cell Biol. 1994 Dec;6(6):847-52. doi: 10.1016/0955-0674(94)90055-8.

Abstract

The regulation of cyclin-dependent kinases is at the heart of cell cycle control and, by inference, the control of cell proliferation. Recent advances in regulation of these kinases have uncovered a group of small proteins that bind to and inhibit them, thus preventing cell cycle progression. Linking these proteins to tumor suppressor functions has provided a much sought after connection between cancer and cell cycle control.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cyclin-Dependent Kinases / antagonists & inhibitors*
  • Humans
  • Mammals
  • Neoplasms / enzymology
  • Saccharomyces cerevisiae

Substances

  • Cyclin-Dependent Kinases