p53 and Rb: their cellular roles

Curr Opin Cell Biol. 1994 Dec;6(6):853-8. doi: 10.1016/0955-0674(94)90056-6.


Within the past year considerable new insights have been gained into the roles the p53 and retinoblastoma tumour suppressors play in determining the fate of cells through their regulation of cell cycle progression, apoptosis and gene expression. Key advances have been achieved in the identification and characterization of functional domains and through functional knockout studies.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology*
  • Humans
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / physiology*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / physiology*


  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53