Genetics of primary aldosteronism

Clin Exp Pharmacol Physiol. 1994 Nov;21(11):915-8. doi: 10.1111/j.1440-1681.1994.tb02466.x.


1. In 1991 we described a familial variety of primary hyperaldosteronism which was not glucocorticoid-suppressible and was associated with adenoma formation, and called it familial hyperaldosteronism type II (FH-II) in order to distinguish it from the glucocorticoid-suppressible variety described in 1966, familial hyperaldosteronism type I (FH-I). 2. In 1992 the genetic basis of FH-I was clarified by description of a hybrid gene. 3. Primary aldosteronism due to bilateral adrenocortical hyperplasia or to aldosterone-producing tumour can be part of the multiple endocrine neoplasia type I syndrome (MEN I), in which loss of heterozygosity has been described on chromosome 11q13. Loss of heterozygosity at the MEN I locus was found in five of 26 aldosterone-producing tumours from our series (by Japanese collaborators). These included two with adrenal cancer and two with FH-II. 4. We recently described an association of aldosterone responsiveness of aldosterone-producing adenomas with renin gene restriction fragment length polymorphisms, suggesting a possible role for renin genotype and intra-adrenal renin gene expression in the development and biochemical expression of some aldosterone-producing tumours. 5. We found abnormal karyotypes in 13 of 32 benign aldosterone-producing adenomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Family
  • Humans
  • Hyperaldosteronism / genetics*
  • Karyotyping*
  • Male
  • Multiple Endocrine Neoplasia / genetics
  • Polymorphism, Restriction Fragment Length
  • Renin / genetics


  • Renin