[Acute psychosis and vigabatrin in childhood]

Pediatr Med Chir. 1994 Sep-Oct;16(5):489-90.
[Article in Italian]


Vigabatrin is an irreversible inhibitor of gamma-aminobutyrate (Gaba) aminotransferase, producing an increase in Gaba concentrations in the brain. It may prove to be an important drug in the treatment of refractory epilepsy, but would be payed attention to behavioural changes noted in association with vigabatrin treatment. Behaviour disturbances, as psychosis, associated to vigabatrin are ben described in adult patients, while are uncommon in childhood. We report a case of acute psychosis occurred in a child in treatment with vigabatrin.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • 4-Aminobutyrate Transaminase / antagonists & inhibitors*
  • Acute Disease
  • Anticonvulsants / adverse effects*
  • Child
  • Epilepsy, Tonic-Clonic / complications
  • Epilepsy, Tonic-Clonic / drug therapy
  • Female
  • Humans
  • Postoperative Complications / drug therapy
  • Psychoses, Substance-Induced / diagnosis
  • Psychoses, Substance-Induced / etiology*
  • Vigabatrin
  • gamma-Aminobutyric Acid / adverse effects
  • gamma-Aminobutyric Acid / analogs & derivatives*


  • Anticonvulsants
  • gamma-Aminobutyric Acid
  • 4-Aminobutyrate Transaminase
  • Vigabatrin