Use of the leishmanin skin test and western blot analysis for epidemiological studies in visceral leishmaniasis areas: experience in a highly endemic focus in Alpes-Maritimes (France)

Trans R Soc Trop Med Hyg. Nov-Dec 1994;88(6):658-9. doi: 10.1016/0035-9203(94)90214-3.

Abstract

Fifty unselected subjects living in Alpes-Maritimes, France, a high risk area for visceral leishmaniasis due to Leishmania infantum, were examined simultaneously by the leishmanin skin test and the Western blot technique in 1993; 32% and 38%, respectively, gave a positive reaction. The concordance of the 2 methods was 82%. Thus, in this high risk area, a large proportion of inhabitants had been exposed to the parasite. The use of these 2 tests should permit the detection of potential cases of reactivated leishmaniasis in prospective follow-up investigations.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Antibodies, Protozoan / blood
  • Antigens, Protozoan*
  • Blotting, Western
  • Child
  • Female
  • France / epidemiology
  • Humans
  • Intradermal Tests
  • Leishmania infantum* / immunology
  • Leishmaniasis, Visceral / diagnosis*
  • Leishmaniasis, Visceral / epidemiology
  • Male
  • Middle Aged
  • Reproducibility of Results

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • leishmanin