Do Human Atrial 5-HT4 Receptors Mediate Arrhythmias?

Trends Pharmacol Sci. 1994 Dec;15(12):451-5. doi: 10.1016/0165-6147(94)90058-2.


Since their first description five years ago, knowledge about human atrial 5-HT4 receptors has increased considerably. Progress has been facilitated by the advent of selective antagonists with high affinity for human atrial 5-HT4 receptors. The receptors have been detected in both right and left atrium where they mediate increases in contractile force. Human sinoatrial 5-HT4 receptors may mediate the tachycardia caused by 5-HT and cisapride, and 5-HT elicits arrhythmias via 5-HT4 receptors in human atrium. In this article, Alberto Kaumann suggests that 5-HT may be involved in the genesis of atrial fibrillation and associated thromboembolic stroke and that both the arrhythmia and stroke could be prevented by inhibiting 5-HT4 receptors.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac / etiology*
  • Heart Atria / ultrastructure*
  • Humans
  • Receptors, Serotonin / physiology*
  • Serotonin Antagonists / pharmacology


  • Receptors, Serotonin
  • Serotonin Antagonists