Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

Vaccine. 1994 Nov;12(15):1419-22. doi: 10.1016/0264-410x(94)90151-1.


The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Bacterial Vaccines / immunology*
  • Cell Line
  • Immune Sera / immunology
  • Macrophages / immunology
  • Mice
  • Mice, Inbred BALB C
  • Opsonin Proteins / immunology*
  • Phagocytosis / immunology
  • Polysaccharides / immunology
  • Quillaja Saponins
  • Saponins / pharmacology*
  • Streptococcus pneumoniae / immunology*


  • Adjuvants, Immunologic
  • Bacterial Vaccines
  • Immune Sera
  • Opsonin Proteins
  • Polysaccharides
  • Quillaja Saponins
  • Saponins
  • Quil A