Meta-analysis of antibiotics in tube thoracostomy

Am Surg. 1995 Mar;61(3):215-9.


The use of antibiotics for patients undergoing tube thoracostomy was determined to be highly variable based on a study conducted at a national meeting of surgeons. A meta-analysis of six randomized studies previously reported was performed. The analysis was carried out using the Confidence Profile Method software FAST*PRO. The meta-analysis was structured using dichotomous outcomes of infectious chest processes (empyema, effusion, pneumonia, wound infection, tracheitis, etc.) versus no infectious chest process in patients with and without antibiotics. The effect measures calculated included actual difference in probabilities, relative risk, percent differences in probabilities, and odds ratio. The results of this meta-analysis suggest that antibiotics should be used in patients undergoing tube thoracostomy. Antibiotic selection should maximize therapy for Staph. aureus. The implementation of this practice guideline will require the co-operation of multiple specialty oriented physicians and surgeons.

Publication types

  • Meta-Analysis

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Chest Tubes*
  • Humans
  • Premedication*
  • Randomized Controlled Trials as Topic
  • Surgical Wound Infection / etiology
  • Surgical Wound Infection / prevention & control
  • Thoracic Diseases / etiology
  • Thoracic Diseases / prevention & control
  • Thoracostomy* / adverse effects


  • Anti-Bacterial Agents