Post-thymectomy autoimmunity: abnormal T-cell homeostasis

Immunol Today. 1995 Feb;16(2):61-7. doi: 10.1016/0167-5699(95)80089-1.


Thymectomy of 3-day-old mice induces organ-specific autoimmune disease, which is characterized by the presence of autoantibodies and T-cell infiltrates in the affected organs. Here, Adriana Bonomo and colleagues propose a new model for the pathogenesis of this syndrome, which integrates many of the homeostatic mechanisms of the immune system, including central and peripheral tolerance, T-cell maturation and exportation from the thymus, as well as lymphocyte recirculation and homing.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Newborn
  • Autoimmune Diseases / immunology*
  • Cell Movement / immunology
  • Homeostasis / immunology
  • Lymphocyte Activation
  • Mice
  • Self Tolerance / immunology
  • T-Lymphocytes / immunology*
  • Thymectomy
  • Thymus Gland / physiology*