Human Herpesvirus 6 in AIDS

Immunol Today. 1995 Feb;16(2):67-71. doi: 10.1016/0167-5699(95)80090-5.


Multiple lines of clinical and experimental evidence suggest that human herpesvirus 6 (HHV-6) may act as an accelerating factor in the natural history of human immunodeficiency virus (HIV) infection. Although, in common with HIV, HHV-6 has a primary tropism for CD4+ T cells, its potential effects on the immune system are broader. For instance, HHV-6 can also infect and kill CD8+ T cells, natural killer cells and mononuclear phagocytes. Here, Paolo Lusso and Robert Gallo suggest that understanding the immunopathogenic role of HHV-6 in the course of HIV infection may shed new light on the complex mechanisms of disease progression in AIDS.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / virology*
  • Herpesviridae Infections / complications*
  • Herpesvirus 6, Human / isolation & purification*
  • Humans