Simple sequences

Curr Opin Genet Dev. 1994 Dec;4(6):832-7. doi: 10.1016/0959-437x(94)90067-1.


Simple sequences (or microsatellites) are stretches of monotonous repetitions of short (1-5bp) nucleotide motifs that are distributed across the whole genome in eukaryotes. They are probably generated by slippage during replication and their primary mutation rate seems to be controlled predominantly by the efficiency of the mismatch repair system. Although most mutations in simple sequence loci appear to be neutral, some mutations in particular stretches have been implicated as having a role in human genetic diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Repair
  • DNA Replication
  • DNA, Satellite / genetics*
  • Humans
  • Models, Genetic
  • Mutagenesis
  • Nucleic Acid Heteroduplexes / genetics
  • Repetitive Sequences, Nucleic Acid / genetics*


  • DNA, Satellite
  • Nucleic Acid Heteroduplexes