Codon usage and genome evolution

Curr Opin Genet Dev. 1994 Dec;4(6):851-60. doi: 10.1016/0959-437x(94)90070-1.


The rates and patterns of evolution at silent sites in codons reveal much about the basic features of molecular evolution. Recent increases in the amount of sequence data available for various species and more precise knowledge of the chromosomal locations of those sequences, coming in particular from genome projects, reveal that some features of molecular evolution vary around the genome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Composition
  • Biological Evolution*
  • Codon / genetics*
  • DNA, Helminth / genetics
  • Dinucleoside Phosphates / metabolism
  • Drosophila / genetics
  • Gene Expression Regulation*
  • Genes, Insect / genetics
  • Genome*
  • Genome, Bacterial
  • Genome, Fungal
  • Genome, Human
  • Humans
  • Mammals / genetics
  • Protein Biosynthesis*
  • Selection, Genetic
  • Species Specificity


  • Codon
  • DNA, Helminth
  • Dinucleoside Phosphates
  • cytidylyl-3'-5'-guanosine