Abstract
RNA genomes evolve largely on the basis of single point mutations introduced by imprecise RNA polymerases, or by recombination. Clusters of certain transitions (biased hypermutations) were detected first in the genomes of persistent viruses, and in the past year have also been found in the genomes of lytic RNA viruses. A cellular RNA-modifying enzyme probably introduces the clustered transitions and thus contributes to the evolution of RNA viruses.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adenosine / metabolism
-
Adenosine Deaminase / metabolism
-
Animals
-
Biological Evolution*
-
Deamination
-
Genome, Viral*
-
Humans
-
Inosine / metabolism
-
Mononegavirales / genetics
-
Mononegavirales / metabolism
-
Point Mutation*
-
RNA Editing
-
RNA Viruses / genetics*
-
RNA Viruses / metabolism
-
RNA, Double-Stranded / biosynthesis
-
RNA, Viral / genetics*
-
RNA, Viral / metabolism
-
RNA-Binding Proteins
Substances
-
RNA, Double-Stranded
-
RNA, Viral
-
RNA-Binding Proteins
-
Inosine
-
ADARB1 protein, human
-
Adenosine Deaminase
-
Adenosine