Mycoplasma genitalium in the joints of two patients with arthritis

Eur J Clin Microbiol Infect Dis. 1994 Dec;13(12):1066-9. doi: 10.1007/BF02111830.


Mycoplasma genitalium was sought in synovial fluids from 13 patients, of whom five had Reiter's syndrome, four had rheumatoid arthritis, and one each had systemic lupus erythematosus, psoriatic arthritis, rheumatic fever and undefined arthritis. The mycoplasma was detected by a PCR assay in the knee joint of a 25-year-old man with Reiter's syndrome, from whom urethral ureaplasmas were isolated and whose synovial fluid mononuclear cells responded to ureaplasmal antigens in a proliferation assay. Mycoplasma genitalium was also detected in the knee joint during an exacerbation of arthritis in a 58-year-old man who had had seronegative juvenile polyarthritis that had evolved to seronegative rheumatoid arthritis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis / microbiology*
  • Arthritis, Reactive / microbiology
  • Arthritis, Rheumatoid / microbiology
  • Ciprofloxacin / therapeutic use
  • Humans
  • Knee Joint / microbiology*
  • Lupus Erythematosus, Systemic / microbiology
  • Male
  • Middle Aged
  • Mycoplasma Infections / complications
  • Mycoplasma Infections / microbiology*
  • Mycoplasma* / isolation & purification
  • Prednisone / therapeutic use
  • Synovial Fluid / microbiology
  • Ureaplasma Infections / complications
  • Ureaplasma Infections / microbiology
  • Ureaplasma urealyticum
  • Urethral Diseases


  • Ciprofloxacin
  • Prednisone