Incorporation of lactate measurement in multi-spin-echo proton spectroscopic imaging

Magn Reson Med. 1995 Jan;33(1):101-7. doi: 10.1002/mrm.1910330115.

Abstract

An improved multi-slice, multi-spin-echo proton spectroscopic imaging method for human brain is presented. The technique allows the reconstruction of lactate images, along with choline plus creatine, N-acetylaspartate, and lipid images from one single data set processed in three separate ways. The discrimination between resonances of lipid protons and lactate methyl protons is based on homonuclear spin-spin coupling. The reliability of the separation of the lipid and lactate contribution depends on the T2 of the lipid resonances. Measurements were performed on a standard 1.5 Tesla clinical scanner on healthy volunteers and a patient with high grade CNS lymphoma, demonstrating the ability to obtain high quality metabolite maps within 11 min.

MeSH terms

  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / analysis
  • Brain / metabolism*
  • Brain Chemistry
  • Brain Neoplasms / metabolism*
  • Choline / analysis
  • Creatine / analysis
  • Humans
  • Image Processing, Computer-Assisted
  • Lactates / analysis*
  • Lactic Acid
  • Lipids / analysis
  • Lymphoma, Non-Hodgkin / metabolism*
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy* / methods
  • Models, Structural
  • Time Factors

Substances

  • Lactates
  • Lipids
  • Aspartic Acid
  • Lactic Acid
  • N-acetylaspartate
  • Creatine
  • Choline