Mechanisms of pyrimethamine resistance in two different strains of Plasmodium berghei

Mol Biochem Parasitol. 1994 Nov;68(1):167-71. doi: 10.1016/0166-6851(94)00163-4.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromosome Mapping
  • Cloning, Molecular
  • Drug Resistance / genetics
  • Folic Acid Antagonists
  • Genes, Protozoan
  • Molecular Sequence Data
  • Multienzyme Complexes / antagonists & inhibitors
  • Multienzyme Complexes / genetics
  • Plasmodium berghei / drug effects*
  • Plasmodium berghei / enzymology
  • Plasmodium berghei / genetics*
  • Plasmodium chabaudi / enzymology
  • Plasmodium chabaudi / genetics
  • Plasmodium falciparum / enzymology
  • Plasmodium falciparum / genetics
  • Point Mutation
  • Pyrimethamine / pharmacology*
  • Sequence Homology, Amino Acid
  • Tetrahydrofolate Dehydrogenase / genetics
  • Thymidylate Synthase / antagonists & inhibitors
  • Thymidylate Synthase / genetics

Substances

  • Folic Acid Antagonists
  • Multienzyme Complexes
  • thymidylate synthase-dihydrofolate reductase
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
  • Pyrimethamine

Associated data

  • GENBANK/U12275