Replacing ganciclovir implants

Ophthalmology. 1995 Mar;102(3):388-92. doi: 10.1016/s0161-6420(95)31010-x.


Purpose: The authors report their surgical experience replacing empty ganciclovir implants in patients with acquired immune deficiency syndrome (AIDS)-related cytomegalovirus (CMV) retinitis.

Methods: A chart review of all patients receiving two or more ganciclovir implants was performed.

Results: Nine eyes in eight patients received two or more implants. The average time before a second implant was needed was 6 months. Cytomegalovirus retinitis was controlled in all patients except one. Three patients required intermittent intravenous exogenous anti-CMV therapy, one for persistent CMV retinitis and two for systemic CMV. Visual acuity of 20/40 or better was maintained in five of eight patients, despite a longstanding history of CMV retinitis.

Conclusion: In this small series, most patients retained good vision after ganciclovir implant replacement.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Clinical Trial, Phase II

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy*
  • Cytomegalovirus Retinitis / drug therapy*
  • Drug Delivery Systems
  • Drug Implants
  • Ganciclovir / administration & dosage*
  • Ganciclovir / therapeutic use
  • Humans
  • Postoperative Complications
  • Recurrence
  • Reoperation
  • Visual Acuity


  • Drug Implants
  • Ganciclovir