Tyrosine kinase inhibition: an approach to drug development

Science. 1995 Mar 24;267(5205):1782-8. doi: 10.1126/science.7892601.

Abstract

Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the immune system. Uncontrolled signaling from receptor tyrosine kinases and intracellular tyrosine kinases can lead to inflammatory responses and to diseases such as cancer, atherosclerosis, and psoriasis. Thus, inhibitors that block the activity of tyrosine kinases and the signaling pathways they activate may provide a useful basis for drug development. This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Catechols / pharmacology
  • Cell Division / drug effects
  • Drug Design*
  • Humans
  • Nitriles / pharmacology
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Signal Transduction / drug effects
  • Structure-Activity Relationship
  • Tyrphostins*

Substances

  • Catechols
  • Nitriles
  • Tyrphostins
  • tyrphostin 47
  • Protein-Tyrosine Kinases