[The solubility and bioequivalence of silymarin preparations]

Arzneimittelforschung. 1995 Jan;45(1):61-4.
[Article in German]


Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular silibinin (CAS 22888-70-6) and tested in vitro for their liberation of active agents. Founded on the results of these tests three products were checked for bioequivalence. Therefore, a typical phase I 3 fold crossover study was performed showing one product (Legalon) to be qualified by an approx. 2 fold higher silibinin availability compared to the two other preparations.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Humans
  • Silymarin / chemistry*
  • Silymarin / pharmacokinetics*
  • Solubility
  • Therapeutic Equivalency


  • Silymarin