Memory of rats with amygdala lesions induced 30 days after footshock-motivated escape training reflects degree of original training

Behav Neurosci. 1994 Dec;108(6):1080-7. doi: 10.1037//0735-7044.108.6.1080.


This experiment was conducted to determine whether the amount of preoperative training influences the effects, on retention, of amygdala lesions induced 30 days after escape training. Rats received 1 or 10 footshock-motivated escape training trials; 30 days later, sham or neurotoxic amygdala lesions were induced. Results of an inhibitory avoidance test performed 4 days after surgery indicated that amygdala lesions impaired retention performance; however, increased preoperative training partially attenuated the retention deficit. Increased preoperative training also attenuated the impairing effects of the lesions on retention assessed in a continuous multiple-trial inhibitory avoidance task given 36 days after the original escape training. The finding that amygdala-lesioned rats remembered the escape training suggests that the amygdala is not a critical locus of the changes underlying the long-term retention of footshock-motivated escape training.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / physiology*
  • Animals
  • Brain Mapping
  • Escape Reaction / physiology*
  • Fear / physiology*
  • Long-Term Potentiation / physiology
  • Male
  • Mental Recall / physiology*
  • Motivation*
  • Motor Activity / physiology
  • Neural Inhibition / physiology
  • Practice, Psychological*
  • Rats
  • Rats, Sprague-Dawley
  • Reaction Time / physiology
  • Retention, Psychology / physiology*