The yeast two-hybrid system for studying protein-protein interactions

Curr Opin Biotechnol. 1995 Feb;6(1):59-64. doi: 10.1016/0958-1669(95)80010-7.

Abstract

A great number of investigators are currently employing the yeast two-hybrid system to study protein-protein interactions. Recent applications and newer configurations of the technique include yeast strains with improved selectivity and screens for false-positive clones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biotechnology / methods
  • DNA / metabolism
  • DNA-Directed RNA Polymerases / metabolism
  • False Positive Reactions
  • Fungal Proteins / metabolism*
  • Genetic Techniques
  • Mammals
  • Proteins / chemistry
  • Proteins / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Transcription Factors / metabolism*
  • Two-Hybrid System Techniques

Substances

  • Fungal Proteins
  • Proteins
  • Transcription Factors
  • DNA
  • DNA-Directed RNA Polymerases