Hepatic changes of mice in the subacute phase of streptozotocin (SZ)-induced diabetes

Exp Toxicol Pathol. 1994 Oct;46(4-5):368-74. doi: 10.1016/s0940-2993(11)80119-3.


Hepatic changes of mice in the subacute phase of streptozotocin (SZ)-induced diabetes were investigated biochemically and pathologically. Biochemically, the contents of serum glucose and of serum and liver lipids increased while the content of liver glycogen decreased in SZ-induced diabetic mice. Histopathologically, hypertrophy of hepatocytes due to an increase in number of intracytoplasmic acidophilic granules was common to SZ-induced diabetic mice. Electron microscopically, these hepatocytes were characterized by a prominent increase in number of mitochondria showing normal structure, a marked decrease of glycogen granules and poorly developed rough endoplasmic reticulum, which were common to so-called oncocytic cells. In some SZ-induced diabetic mice, bile duct hyperplasia with an appearance of cytomegalic hepatocytes was also observed.

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Diabetes Mellitus, Experimental / complications
  • Diabetes Mellitus, Experimental / pathology*
  • Endoplasmic Reticulum / drug effects
  • Glycogen / analysis
  • Hypertrophy / pathology
  • Lipids / analysis
  • Liver / chemistry
  • Liver / drug effects*
  • Liver / pathology*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Microscopy, Electron
  • Organ Size / drug effects
  • Streptozocin / toxicity*
  • Weight Gain / drug effects


  • Blood Glucose
  • Lipids
  • Streptozocin
  • Glycogen