Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine

Brain Res. 1994 Dec 5;665(2):315-8. doi: 10.1016/0006-8993(94)91354-4.


Cerebral blood flow and glucose utilization were measured in rat neocortex, hippocampus and striatum following methylenedioxymethamphetamine injection (5 mg/kg, i.v.), using the tracers [14C]iodoantipyrine and [14C]2-deoxyglucose, respectively. In control rats, blood flow was coupled to glucose metabolism, but in methylenedioxymethamphetamine-treated rats, marked hyperperfusion was measured in frontal and parietal cortex with no change in glucose use. This suggests that methylenedioxymethamphetamine has the potential to disrupt cerebrovascular control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Brain / metabolism
  • Cerebral Cortex / blood supply*
  • Cerebrovascular Circulation / drug effects
  • Glucose / metabolism
  • Hyperemia / chemically induced*
  • Male
  • Motor Activity / drug effects
  • N-Methyl-3,4-methylenedioxyamphetamine* / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors
  • Tissue Distribution


  • Glucose
  • N-Methyl-3,4-methylenedioxyamphetamine