The role of ornithine decarboxylase in c-Myc-induced apoptosis

Curr Top Microbiol Immunol. 1995;194:283-90. doi: 10.1007/978-3-642-79275-5_33.

Abstract

Translocations or amplifications which activate members of the myc gene family are common in human cancer. c-Myc is a central regulator of normal cell proliferation and differentiation (Luscher and Eisenman, 1991; Marcu et al. 1992) and can induce apoptosis (Askew et al. 1991, 1993; Evan et al. 1992; Bissonette et al. 1992; Shi et al. 1992). c-Myc is a transcription factor (Amati et al. 1992; Kretzner et al. 1992), however, the targets regulated by c-Myc which mediate its activities are not known. Here, we discuss the role of the ornithine decarboxylase (ODC) gene as a direct transcriptional target of c-Myc and demonstrate a role for ODC enzyme activity in c-Myc-induced apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis*
  • Gene Expression Regulation
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / enzymology
  • Interleukin-3 / physiology
  • Mice
  • Ornithine Decarboxylase / physiology*
  • Proto-Oncogene Proteins c-myc / physiology*
  • Transcription Factors / physiology*
  • Transcription, Genetic*

Substances

  • Interleukin-3
  • Proto-Oncogene Proteins c-myc
  • Transcription Factors
  • Ornithine Decarboxylase