Carbon regulation of penicillin biosynthesis in Aspergillus nidulans: a minor effect of mutations in creB and creC

FEMS Microbiol Lett. 1995 Feb 1;126(1):63-7. doi: 10.1016/0378-1097(94)00527-x.


Transcription of the Aspergillus nidulans ipnA gene is under carbon regulation. Loss-of-function mutations in creB or creC do not cause full derepression of ipnA transcript levels in sucrose-grown mycelia and do not elevate repressed penicillin levels, indicating that neither of these genes plays a major regulatory role in penicillin biosynthesis. However, these mutations reduce external pH acidification, accelerate sucrose degradation and result in extracellular accumulation of resulting D-glucose and D-fructose. These effects would explain the partial elevation of carbon-repressed ipnA transcript levels observed in strains carrying creB- or creC- mutations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus nidulans / drug effects
  • Aspergillus nidulans / genetics
  • Aspergillus nidulans / metabolism*
  • Enzyme Repression
  • Gene Expression Regulation, Bacterial*
  • Genes, Bacterial / genetics*
  • Genes, Regulator / genetics
  • Hydrogen-Ion Concentration
  • Mutation
  • Oxidoreductases / biosynthesis
  • Oxidoreductases / genetics*
  • Penicillins / biosynthesis*
  • RNA, Messenger / analysis
  • Sucrose / metabolism
  • Sucrose / pharmacology


  • Penicillins
  • RNA, Messenger
  • Sucrose
  • Oxidoreductases
  • isopenicillin N synthetase