Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report

J Toxicol Clin Toxicol. 1995;33(2):179-83. doi: 10.3109/15563659509000470.


Propoxyphene overdose is known to cause widening of the QRS complex on ECG. We report a case of a 54-year-old female who ingested approximately 100 propoxyphene hydrochloride tablets in a suicide attempt. She developed a wide complex dysrhythmia which responded to sodium bicarbonate therapy. Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / poisoning
  • Arrhythmias, Cardiac / blood
  • Arrhythmias, Cardiac / chemically induced*
  • Arrhythmias, Cardiac / drug therapy*
  • Dextropropoxyphene / poisoning*
  • Drug Interactions
  • Electrocardiography / drug effects*
  • Female
  • Fluoxetine / poisoning
  • Humans
  • Middle Aged
  • Sodium Bicarbonate / therapeutic use*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Fluoxetine
  • Sodium Bicarbonate
  • Dextropropoxyphene