A Comparative Pharmacological Investigation of Ashwagandha and Ginseng

J Ethnopharmacol. 1994 Dec;44(3):131-5. doi: 10.1016/0378-8741(94)01119-2.


The aqueous suspensions of roots of an Indian drug Ashwagandha and the Korean drug Ginseng were tested comparatively for 2 pharmacological activities, namely the anti-stress activity by the 'mice swimming endurance test' and anabolic activity by noting gain in body weights and levator ani muscle in rats. A significant increase in mice swimming time was shown by Ginseng (P < 0.001) and Ashwagandha (P < 0.01) as compared to the control group. Significant increase in body weights in the Ashwagandha treated group (P < 0.05) was better than Ginseng (P < 0.5). Gain in wet weights of the levator ani muscle were also significant in Ginseng (P < 0.001) and Ashwagandha (P < 0.01) treated groups, however, the weight gain of dried levator ani muscles showed comparable results for both these drugs (P < 0.01).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Body Weight / drug effects
  • Chromatography, Thin Layer
  • Male
  • Mice
  • Muscles / drug effects
  • Panax*
  • Physical Exertion / drug effects*
  • Plant Extracts*
  • Plants, Medicinal*
  • Rats
  • Stress, Physiological / prevention & control
  • Swimming
  • Withania*


  • Plant Extracts
  • Ashwagandha