Sleep pattern and supplementary oxygen requirements in infants with chronic neonatal lung disease

Lancet. 1995 Apr 1;345(8953):831-2. doi: 10.1016/s0140-6736(95)92966-5.


Seven infants with chronic neonatal lung disease and baseline oxygen saturation greater than 90% were studied with overnight polysomnography in their prescribed oxygen environment, and on a second night with 0.25 L/min additional oxygen. All had sleep fragmentation and decreased rapid-eye-movement (REM) sleep, which was reversed after the increased oxygen. Sleep duration (p < 0.003), percentage REM sleep (p < 0.001), and mean REM sleep period length (p < 0.001) were increased, and arousals in REM sleep decreased (p < 0.05), with improved oxygenation. We conclude that, in infants with chronic neonatal lung disease, arousal mechanisms minimise oxygen desaturation but induce sleep disruption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arousal
  • Blood Gas Monitoring, Transcutaneous
  • Bronchopulmonary Dysplasia / physiopathology
  • Bronchopulmonary Dysplasia / therapy
  • Chronic Disease
  • Humans
  • Infant
  • Infant, Newborn
  • Lung Diseases / physiopathology
  • Lung Diseases / therapy*
  • Oxygen Inhalation Therapy*
  • Polysomnography
  • Sleep / physiology*
  • Sleep, REM / physiology