Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+

Mol Cell Biochem. 1994 Sep;138(1-2):229-35. doi: 10.1007/BF00928466.


Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
  • Adenosine Diphosphate Ribose / analogs & derivatives*
  • Adenosine Diphosphate Ribose / antagonists & inhibitors
  • Adenosine Diphosphate Ribose / physiology
  • Animals
  • Antigens, CD*
  • Antigens, Differentiation / metabolism
  • Calcium / metabolism*
  • Cyclic ADP-Ribose
  • Humans
  • Membrane Glycoproteins
  • Molecular Structure
  • N-Glycosyl Hydrolases / metabolism
  • NAD / metabolism*
  • Receptors, Cell Surface / metabolism


  • Antigens, CD
  • Antigens, Differentiation
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • cyclic ADP-ribose receptor
  • NAD
  • Cyclic ADP-Ribose
  • Adenosine Diphosphate Ribose
  • N-Glycosyl Hydrolases
  • ADP-ribosyl Cyclase
  • CD38 protein, human
  • ADP-ribosyl Cyclase 1
  • Calcium