Poly(ADP-ribose): historical perspective

Mol Cell Biochem. 1994 Sep;138(1-2):5-12. doi: 10.1007/BF00928437.


The early historical background of the discovery of poly(ADP-ribose) and the following development of science on poly(ADP-ribose) are reviewed. Fundamental knowledge on the natures of poly(ADP-ribose), poly(ADP-ribose) polymerase and enzymes degrading poly(ADP-ribose) are summarized with brief description on the methodology for their purification and characterization. Future prospect of research on biological significance of poly(ADP-ribose) has also been discussed briefly.

Publication types

  • Historical Article

MeSH terms

  • History, 20th Century
  • Molecular Structure
  • Poly Adenosine Diphosphate Ribose / chemistry
  • Poly Adenosine Diphosphate Ribose / history*


  • Poly Adenosine Diphosphate Ribose